The human genome will not be a linear construction, however a three-dimensional construction by way of advanced folding and meeting. Chromosome construction seize expertise can detect the three-dimensional building of chromatin. Hello-C sequencing information of varied tumors point out that the chromatin topology related domains modified throughout tumor development and is expounded to repeat quantity variation. As well as, transformation of the genomic compartment is expounded to gene expression. Nonetheless, present researches on three-dimensional buildings of tumoral chromatin are nonetheless within the stage of exploration, and a few conclusions are too superficial to be utilized to the clinic instantly, which requires additional examine.
Research of nuclear structure utilizing chromosome conformation seize strategies have offered an in depth view of how chromatin folds within the 3D nuclear area. New variants of this expertise now afford unprecedented decision and permit the identification of ever smaller folding domains that supply new insights into the mechanisms by which this group is established and maintained. Right here we assessment latest outcomes on this quickly evolving discipline with an emphasis on CTCF operate, with the objective of gaining a mechanistic understanding of the rules by which chromatin is folded within the eukaryotic nucleus. Correct meeting of mitotic spindles requires microtubule nucleation not solely on the centrosomes but in addition round chromatin.
On this examine, we discovered that the Drosophila tubulin-specific chaperone dTBCE is required for the enrichment of tubulin within the nuclear area after nuclear envelope breakdown and for subsequent promotion of spindle microtubule nucleation. These occasions depend upon the CAP-Gly motif present in dTBCE and are regulated by Ran and lamin proteins. Our information counsel that in early mitosis, dTBCE and nuclear pore proteins grow to be enriched within the nucleus, the place they work together with the Ran GTPase to advertise dynamic tubulin enrichment. We suggest that this novel mechanism enhances microtubule nucleation round chromatin, thereby facilitating mitotic spindle meeting.
Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
Senescence is a state of steady proliferative arrest, usually accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-promoter interactions, facilitated by chromatin loops, play a key function in gene regulation however their relevance in senescence stays elusive. Right here, we use Hello-C to point out that oncogenic RAS-induced senescence in human diploid fibroblasts is accompanied by intensive enhancer-promoter rewiring, which is carefully related with dynamic cohesin binding to the genome.
We discover de novo cohesin peaks usually on the 3′ finish of a subset of lively genes. RAS-induced de novo cohesin peaks are transcription-dependent and enriched for senescence-associated genes, exemplified by IL1B, the place de novo cohesin binding is concerned in new loop formation. Related IL1B induction with de novo cohesin look and new loop formation are noticed in terminally differentiated macrophages, however not TNFα-treated cells. These outcomes counsel that RAS-induced senescence represents a cell destiny determination-like course of characterised by a singular gene expression profile and 3D genome folding signature, mediated partially by way of cohesin redistribution on chromatin.
The massive quantity of information acquired by high-throughput sequencing requires information discount for efficient evaluation. Right here we give a clustering algorithm for genome-wide open chromatin information utilizing a brand new information discount technique. This technique regards the genome as a string of 1s and 0s primarily based on a set of peaks and calculates the Hamming distances between the strings. This algorithm with the systematically optimized set of peaks permits us to quantitatively consider variations between samples of hematopoietic cells and classify cell varieties, doubtlessly resulting in a greater understanding of leukemia pathogenesis.
Three-dimensional chromatin organization in cardiac development and disease
Latest technological developments within the discipline of chromatin biology have rewritten the textbook on nuclear group. We now respect that the folding of chromatin within the three-dimensional area (i.e. its 3D “structure”) is non-random, hierarchical, and extremely advanced. Whereas 3D chromatin construction is partially encoded within the main sequence and thereby broadly conserved throughout cell varieties and states, a considerable portion of the genome appears to be dynamic throughout improvement or in illness. Furthermore, there’s rising proof that at the very least a few of the 3D construction of chromatin is functionally linked to gene regulation, each being modulated by and impacting on a number of nuclear processes (together with DNA replication, transcription, and RNA splicing).
In recent times, these new ideas have nourished a number of investigations concerning the purposeful function of 3D chromatin topology dynamics within the coronary heart throughout improvement and illness. This assessment goals to supply a complete overview of our present understanding on this discipline, and to debate how this information can inform additional analysis in addition to scientific apply. Past being the product of gene expression, RNA may affect the regulation of chromatin. Nearly all of the human genome has the capability to be transcribed and nearly all of the non-protein-coding transcripts made by RNA Polymerase II are enriched within the nucleus.
 DiscoveryProbe™ Cell Cycle Library |
|
L1037-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 3152 |
|
Description: Screening Library |
DiscoveryProbe™ Cell Cycle Library |
|
L1037-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 3944 |
|
Description: Screening Library |
DiscoveryProbe™ Cell Cycle Library |
|
L1037-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 7048 |
|
Description: Screening Library |
 DiscoveryProbe? MAPK Inhibitor Library |
|
L1043-5 |
ApexBio |
5 mg/well |
EUR 5488.8 |
 DiscoveryProbe? Natural Product Library |
|
L1039-5 |
ApexBio |
5 mg/well |
EUR 12866.4 |
 DiscoveryProbe™ Angiogenesis Library |
|
L1047-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 872 |
|
Description: Screening Library |
DiscoveryProbe™ Angiogenesis Library |
|
L1047-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 1088 |
|
Description: Screening Library |
DiscoveryProbe™ Angiogenesis Library |
|
L1047-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 1968 |
|
Description: Screening Library |
 DiscoveryProbe? NF-?B Signaling Library |
|
L1044-5 |
ApexBio |
5 mg/well |
EUR 3970.8 |
 DiscoveryProbe? Kinase Inhibitor Library |
|
L1024-5 |
ApexBio |
5 mg/well |
EUR 17473.2 |
 DiscoveryProbe™ GPCR Compound Library |
|
L1025-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 4334.4 |
|
Description: Screening Library |
DiscoveryProbe™ GPCR Compound Library |
|
L1025-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 5412.8 |
|
Description: Screening Library |
DiscoveryProbe™ GPCR Compound Library |
|
L1025-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 9780 |
|
Description: Screening Library |
 DiscoveryProbe? JAK/STAT Compound Library |
|
L1041-5 |
ApexBio |
5 mg/well |
EUR 6184.8 |
 DiscoveryProbe™ MAPK Inhibitor Library |
|
L1043-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 1320 |
|
Description: Screening Library |
DiscoveryProbe™ MAPK Inhibitor Library |
|
L1043-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 1648 |
|
Description: Screening Library |
DiscoveryProbe™ MAPK Inhibitor Library |
|
L1043-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 2968 |
|
Description: Screening Library |
 DiscoveryProbe? Bioactive Compound Library |
|
L1022-5 |
ApexBio |
5 mg/well |
EUR 65623.2 |
 DiscoveryProbe? Neuronal Signaling Library |
|
L1026-5 |
ApexBio |
5 mg/well |
EUR 13840.8 |
 DiscoveryProbe? Autophagy Compound Library |
|
L1031-5 |
ApexBio |
5 mg/well |
EUR 31380 |
 DiscoveryProbe? Protease Inhibitor Library |
|
L1035-5 |
ApexBio |
5 mg/well |
EUR 9414 |
 DiscoveryProbe? Apoptosis Compound Library |
|
L1036-5 |
ApexBio |
5 mg/well |
EUR 9664.8 |
 DiscoveryProbe™ Natural Product Library |
|
L1039-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 2512 |
|
Description: Screening Library |
DiscoveryProbe™ Natural Product Library |
|
L1039-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 3144 |
|
Description: Screening Library |
DiscoveryProbe™ Natural Product Library |
|
L1039-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 5680 |
|
Description: Screening Library |
 DiscoveryProbe? Stem Cell Compound Library |
|
L1040-5 |
ApexBio |
5 mg/well |
EUR 12170.4 |
 DiscoveryProbe? FDA-approved Drug Library |
|
L1021-0.05 |
ApexBio |
50 uL/well(10 mM solution) |
EUR 4514.4 |
|
Description: DiscoveryProbe? FDA-approved drug library includes 1496 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS). It can be used to find new targets for old drugs. The bioactivity and safety of these drugs were confirmed by clinical trials. |
DiscoveryProbe? FDA-approved Drug Library |
|
L1021-5 |
ApexBio |
5 mg/well |
EUR 15789.6 |
|
Description: DiscoveryProbe? FDA-approved drug library includes 1496 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS). It can be used to find new targets for old drugs. The bioactivity and safety of these drugs were confirmed by clinical trials. |
 DiscoveryProbe™ Kinase Inhibitor Library |
|
L1024-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 5320 |
|
Description: Screening Library |
DiscoveryProbe™ Kinase Inhibitor Library |
|
L1024-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 6648 |
|
Description: Screening Library |
DiscoveryProbe™ Kinase Inhibitor Library |
|
L1024-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 12008 |
|
Description: Screening Library |
 DiscoveryProbe? Epigenetics Compound Library |
|
L1029-5 |
ApexBio |
5 mg/well |
EUR 16764 |
 DiscoveryProbe? Histone Modification Library |
|
L1038-5 |
ApexBio |
5 mg/well |
EUR 5210.4 |
 DiscoveryProbe? Ion Channel Compound Library |
|
L1030-5 |
ApexBio |
5 mg/well |
EUR 15482.4 |
 DiscoveryProbe? Natural Product Library Plus |
|
L1049-5 |
ApexBio |
5 mg/well |
EUR 9786 |
 DiscoveryProbe™ JAK/STAT Compound Library |
|
L1041-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 1352 |
|
Description: Screening Library |
DiscoveryProbe™ JAK/STAT Compound Library |
|
L1041-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 1688 |
|
Description: Screening Library |
DiscoveryProbe™ JAK/STAT Compound Library |
|
L1041-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 3016 |
|
Description: Screening Library |
 DiscoveryProbe™ NF-κB Signaling Library |
|
L1044-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 768 |
|
Description: Screening Library |
DiscoveryProbe™ NF-κB Signaling Library |
|
L1044-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 960 |
|
Description: Screening Library |
DiscoveryProbe™ NF-κB Signaling Library |
|
L1044-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 1720 |
|
Description: Screening Library |
 DiscoveryProbe™ Bioactive Compound Library |
|
L1022-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 12880 |
|
Description: Screening Library |
DiscoveryProbe™ Bioactive Compound Library |
|
L1022-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 16096 |
|
Description: Screening Library |
DiscoveryProbe™ Bioactive Compound Library |
|
L1022-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 28960 |
|
Description: Screening Library |
 DiscoveryProbe™ Neuronal Signaling Library |
|
L1026-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 2712 |
|
Description: Screening Library |
DiscoveryProbe™ Neuronal Signaling Library |
|
L1026-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 3392 |
|
Description: Screening Library |
DiscoveryProbe™ Neuronal Signaling Library |
|
L1026-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 6080 |
|
Description: Screening Library |
 DiscoveryProbe™ Autophagy Compound Library |
|
L1031-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 6136 |
|
Description: Screening Library |
DiscoveryProbe™ Autophagy Compound Library |
|
L1031-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 7672 |
|
Description: Screening Library |
DiscoveryProbe™ Autophagy Compound Library |
|
L1031-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 13840 |
|
Description: Screening Library |
 DiscoveryProbe™ Protease Inhibitor Library |
|
L1035-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 9360 |
|
Description: Screening Library |
DiscoveryProbe™ Protease Inhibitor Library |
|
L1035-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 11696 |
|
Description: Screening Library |
DiscoveryProbe™ Protease Inhibitor Library |
|
L1035-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 20880 |
|
Description: Screening Library |
 DiscoveryProbe™ Apoptosis Compound Library |
|
L1036-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 6952 |
|
Description: Screening Library |
DiscoveryProbe™ Apoptosis Compound Library |
|
L1036-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 8688 |
|
Description: Screening Library |
DiscoveryProbe™ Apoptosis Compound Library |
|
L1036-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 15600 |
|
Description: Screening Library |
 DiscoveryProbe? DNA Damage/DNA Repair Library |
|
L1033-5 |
ApexBio |
5 mg/well |
EUR 10806 |
 DiscoveryProbe™ Stem Cell Compound Library |
|
L1040-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 2376 |
|
Description: Screening Library |
DiscoveryProbe™ Stem Cell Compound Library |
|
L1040-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 2968 |
|
Description: Screening Library |
DiscoveryProbe™ Stem Cell Compound Library |
|
L1040-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 5360 |
|
Description: Screening Library |
 DiscoveryProbe? Anti-cancer Compound Library |
|
L1023-5 |
ApexBio |
5 mg/well |
EUR 56853.6 |
 DiscoveryProbe™ FDA-approved Drug Library |
|
L1021-.02 |
ApexBio |
20uL/well(10 mM solution),96 Well Microplates |
EUR 1488 |
|
Description: Screening Library |
DiscoveryProbe™ FDA-approved Drug Library |
|
L1021-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4392 |
|
Description: Screening Library |
DiscoveryProbe™ FDA-approved Drug Library |
|
L1021-.1-1 |
ApexBio |
100uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 5496 |
|
Description: Screening Library |
DiscoveryProbe™ FDA-approved Drug Library |
|
L1021-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 9848 |
|
Description: Screening Library |
 DiscoveryProbe? PI3K/Akt/mTOR Compound Library |
|
L1034-5 |
ApexBio |
5 mg/well |
EUR 10360.8 |
 DiscoveryProbe™ Epigenetics Compound Library |
|
L1029-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 3608 |
|
Description: Screening Library |
DiscoveryProbe™ Epigenetics Compound Library |
|
L1029-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4512 |
|
Description: Screening Library |
DiscoveryProbe™ Epigenetics Compound Library |
|
L1029-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 8160 |
|
Description: Screening Library |
 DiscoveryProbe™ Histone Modification Library |
|
L1038-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 1096 |
|
Description: Screening Library |
DiscoveryProbe™ Histone Modification Library |
|
L1038-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 1368 |
|
Description: Screening Library |
DiscoveryProbe™ Histone Modification Library |
|
L1038-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 2424 |
|
Description: Screening Library |
 DiscoveryProbe™ Ion Channel Compound Library |
|
L1030-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 3040 |
|
Description: Screening Library |
DiscoveryProbe™ Ion Channel Compound Library |
|
L1030-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 3800 |
|
Description: Screening Library |
DiscoveryProbe™ Ion Channel Compound Library |
|
L1030-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 6784 |
|
Description: Screening Library |
 DiscoveryProbe™ Natural Product Library Plus |
|
L1039P-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 6812 |
|
Description: Screening Library |
DiscoveryProbe™ Natural Product Library Plus |
|
L1039P-.1 |
ApexBio |
100uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 8509.6 |
|
Description: Screening Library |
DiscoveryProbe™ Natural Product Library Plus |
|
L1039P-.25 |
ApexBio |
250uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 15378.4 |
|
Description: Screening Library |
 DiscoveryProbe? Anti-diabetic Compound Library |
|
L1046-5 |
ApexBio |
5 mg/well |
EUR 1939.2 |
 DiscoveryProbe? TGF-beta/Smad Compound Library |
|
L1045-5 |
ApexBio |
5 mg/well |
EUR 4500 |
 DiscoveryProbe™ Anti-Virus Compound Library |
|
L1050-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 4164.8 |
|
Description: Screening Library |
DiscoveryProbe™ Anti-Virus Compound Library |
|
L1050-.1 |
ApexBio |
100uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 5213.6 |
|
Description: Screening Library |
DiscoveryProbe™ Anti-Virus Compound Library |
|
L1050-.25 |
ApexBio |
250uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 9377.6 |
|
Description: Screening Library |
 DiscoveryProbe™ DNA Damage/DNA Repair Library |
|
L1033-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 5584 |
|
Description: Screening Library |
DiscoveryProbe™ DNA Damage/DNA Repair Library |
|
L1033-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 6976 |
|
Description: Screening Library |
DiscoveryProbe™ DNA Damage/DNA Repair Library |
|
L1033-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 12464 |
|
Description: Screening Library |
 DiscoveryProbe? Anti-infection Compound Library |
|
L1027-5 |
ApexBio |
5 mg/well |
EUR 19548 |
 DiscoveryProbe? Tyrosine Kinase Inhibitor Library |
|
L1028-5 |
ApexBio |
5 mg/well |
EUR 15093.6 |
 DiscoveryProbe™ Anti-cancer Compound Library |
|
L1023-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 11176 |
|
Description: Screening Library |
DiscoveryProbe™ Anti-cancer Compound Library |
|
L1023-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 13968 |
|
Description: Screening Library |
DiscoveryProbe™ Anti-cancer Compound Library |
|
L1023-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 25120 |
|
Description: Screening Library |
 DiscoveryProbe™ PI3K/Akt/mTOR Compound Library |
|
L1034-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 2200 |
|
Description: Screening Library |
DiscoveryProbe™ PI3K/Akt/mTOR Compound Library |
|
L1034-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 2752 |
|
Description: Screening Library |
DiscoveryProbe™ PI3K/Akt/mTOR Compound Library |
|
L1034-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 4912 |
|
Description: Screening Library |
 DiscoveryProbe™ Ubiquitination Compound Library |
|
L1049-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 1536 |
|
Description: Screening Library |
DiscoveryProbe™ Ubiquitination Compound Library |
|
L1049-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 1920 |
|
Description: Screening Library |
DiscoveryProbe™ Ubiquitination Compound Library |
|
L1049-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 3456 |
|
Description: Screening Library |
 DiscoveryProbe™ Bioactive Compound Library Plus |
|
L1022P-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 17895.2 |
|
Description: Screening Library |
DiscoveryProbe™ Bioactive Compound Library Plus |
|
L1022P-.1 |
ApexBio |
100uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 22368.8 |
|
Description: Screening Library |
DiscoveryProbe™ Bioactive Compound Library Plus |
|
L1022P-.25 |
ApexBio |
250uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 39942.4 |
|
Description: Screening Library |
 DiscoveryProbe™ Autophagy Compound Library Plus |
|
L1031P-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 10040 |
|
Description: Screening Library |
DiscoveryProbe™ Autophagy Compound Library Plus |
|
L1031P-.1 |
ApexBio |
100uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 12552 |
|
Description: Screening Library |
DiscoveryProbe™ Autophagy Compound Library Plus |
|
L1031P-.25 |
ApexBio |
250uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 22640 |
|
Description: Screening Library |
 DiscoveryProbe™ Stem Cell Compound Library Plus |
|
L1040P-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 3736 |
|
Description: Screening Library |
DiscoveryProbe™ Stem Cell Compound Library Plus |
|
L1040P-.1 |
ApexBio |
100uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 4672 |
|
Description: Screening Library |
DiscoveryProbe™ Stem Cell Compound Library Plus |
|
L1040P-.25 |
ApexBio |
250uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 8432 |
|
Description: Screening Library |
 DiscoveryProbe? Apoptosis-related Compounds Panel |
|
L1002-5 |
ApexBio |
5 mg/well |
EUR 3120 |
|
Description: A wide range of well-characterized bioactive molecules that covers various targets related to apoptosis, including caspase, MDM2 and Bcl-2 etc. Facilitate your research towards the insights of cancer, degenerative diseases and autoimmunity etc. |
 DiscoveryProbe? Stem Cell-related Compounds Panel |
|
L1017-5 |
ApexBio |
5 mg/well |
EUR 6824.4 |
|
Description: A wide range of well-characterized bioactive molecules that covers various targets related to stem cell, including hedgehog, smoothened and Wnt/?-catenin etc. Facilitate your research towards the insights of cell proliferation, growth and differentiation etc. |
 DiscoveryProbe™ Anti-diabetic Compound Library |
|
L1046-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 1264 |
|
Description: Screening Library |
DiscoveryProbe™ Anti-diabetic Compound Library |
|
L1046-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 1584 |
|
Description: Screening Library |
DiscoveryProbe™ Anti-diabetic Compound Library |
|
L1046-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 2848 |
|
Description: Screening Library |
 DiscoveryProbe™ TGF-beta/Smad Compound Library |
|
L1045-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 1080 |
|
Description: Screening Library |
DiscoveryProbe™ TGF-beta/Smad Compound Library |
|
L1045-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 1352 |
|
Description: Screening Library |
DiscoveryProbe™ TGF-beta/Smad Compound Library |
|
L1045-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 2408 |
|
Description: Screening Library |
 DiscoveryProbe? Metabolism-related Compounds Panel |
|
L1013-5 |
ApexBio |
5 mg/well |
EUR 7617.6 |
|
Description: A wide range of well-characterized bioactive molecules that covers various targets related to metabolism, including PPAR, HMG-CoA reductase, HSP, PDE and DHFR etc. Facilitate your research towards the insights of diabetes, hypertension ad hormone regulation etc. |
 DiscoveryProbe™ Anti-infection Compound Library |
|
L1027-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 3856 |
|
Description: Screening Library |
DiscoveryProbe™ Anti-infection Compound Library |
|
L1027-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4816 |
|
Description: Screening Library |
DiscoveryProbe™ Anti-infection Compound Library |
|
L1027-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 8640 |
|
Description: Screening Library |
 DiscoveryProbe™ Tyrosine Kinase Inhibitor Library |
|
L1028-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 3696 |
|
Description: Screening Library |
DiscoveryProbe™ Tyrosine Kinase Inhibitor Library |
|
L1028-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4616 |
|
Description: Screening Library |
DiscoveryProbe™ Tyrosine Kinase Inhibitor Library |
|
L1028-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 8232 |
|
Description: Screening Library |
 DiscoveryProbe™ Ion Channel Compound Library Plus |
|
L1030P-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 4816 |
|
Description: Screening Library |
DiscoveryProbe™ Ion Channel Compound Library Plus |
|
L1030P-.1 |
ApexBio |
100uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 6016 |
|
Description: Screening Library |
DiscoveryProbe™ Ion Channel Compound Library Plus |
|
L1030P-.25 |
ApexBio |
250uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 10736 |
|
Description: Screening Library |
 DiscoveryProbe? Metabolism-related Compound Library |
|
L1032-5 |
ApexBio |
5 mg/well |
EUR 24002.4 |
 DiscoveryProbe™ Clinical & FDA approved Drug Library |
|
L1052-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 5968 |
|
Description: Screening Library |
DiscoveryProbe™ Clinical & FDA approved Drug Library |
|
L1052-.1 |
ApexBio |
100uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 7464 |
|
Description: Screening Library |
DiscoveryProbe™ Clinical & FDA approved Drug Library |
|
L1052-.25 |
ApexBio |
250uL/well(10 mM solution),96 Well Racks With Screw Cap |
EUR 13376 |
|
Description: Screening Library |
 DiscoveryProbe? Angiogenesis-related Compounds Panel |
|
L1001-5 |
ApexBio |
5 mg/well |
EUR 1278 |
|
Description: A wide range of well-characterized bioactive molecules that covers various targets related to angiogenesis, including Btk, integrin and HIF-1 etc. Facilitate your research towards the insights of tumorigenesis, cardiovascular disease and wound repair etc. |
 DiscoveryProbe? Neuroscience-related Compounds Panel |
|
L1015-5 |
ApexBio |
5 mg/well |
EUR 10249.2 |
|
Description: A wide range of well-characterized bioactive molecules that covers various targets related to neuroscience, including 5-HT Receptor, Amyloid ?, GABA and COX etc. Facilitate your research towards the insights of Alzheimer disease, Parkinson's disease and epilepsy etc. |
 DiscoveryProbe? MAPK Signaling Pathway Compounds Panel |
|
L1020-5 |
ApexBio |
5 mg/well |
EUR 5320.8 |
|
Description: A wide range of well-characterized bioactive molecules that covers various targets on the MAPK signaling pathway, including MEK1/2, p38 and Raf etc. Facilitate your research towards the insights of cell proliferation, differentiation, apoptosis and motility etc. |
 DiscoveryProbe™ Anti-cancer Compound Library Plus |
|
L1023P-.096 |
ApexBio |
100uL/well(10 mM solution),96 Well Deep Well Plate |
EUR 17104 |
|
Description: Screening Library |
Many chromatin regulators can bind to those ncRNAs within the nucleus; in some circumstances, there are clear examples of direct RNA-mediated chromatin regulation mechanisms stemming from these interactions, whereas others have but to be decided. Latest research have highlighted examples of chromatin regulation through RNA matchmaking, a time period we use broadly right here to explain intermolecular base-pairing interactions between one RNA molecule and an RNA or DNA match.
