The human genome will not be a linear construction, however a three-dimensional construction by way of advanced folding and meeting. Chromosome construction seize expertise can detect the three-dimensional building of chromatin. Hello-C sequencing information of varied tumors point out that the chromatin topology related domains modified throughout tumor development and is expounded to repeat quantity variation. As well as, transformation of the genomic compartment is expounded to gene expression. Nonetheless, present researches on three-dimensional buildings of tumoral chromatin are nonetheless within the stage of exploration, and a few conclusions are too superficial to be utilized to the clinic instantly, which requires additional examine.
Research of nuclear structure utilizing chromosome conformation seize strategies have offered an in depth view of how chromatin folds within the 3D nuclear area. New variants of this expertise now afford unprecedented decision and permit the identification of ever smaller folding domains that supply new insights into the mechanisms by which this group is established and maintained. Right here we assessment latest outcomes on this quickly evolving discipline with an emphasis on CTCF operate, with the objective of gaining a mechanistic understanding of the rules by which chromatin is folded within the eukaryotic nucleus. Correct meeting of mitotic spindles requires microtubule nucleation not solely on the centrosomes but in addition round chromatin.
On this examine, we discovered that the Drosophila tubulin-specific chaperone dTBCE is required for the enrichment of tubulin within the nuclear area after nuclear envelope breakdown and for subsequent promotion of spindle microtubule nucleation. These occasions depend upon the CAP-Gly motif present in dTBCE and are regulated by Ran and lamin proteins. Our information counsel that in early mitosis, dTBCE and nuclear pore proteins grow to be enriched within the nucleus, the place they work together with the Ran GTPase to advertise dynamic tubulin enrichment. We suggest that this novel mechanism enhances microtubule nucleation round chromatin, thereby facilitating mitotic spindle meeting.
Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
Senescence is a state of steady proliferative arrest, usually accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-promoter interactions, facilitated by chromatin loops, play a key function in gene regulation however their relevance in senescence stays elusive. Right here, we use Hello-C to point out that oncogenic RAS-induced senescence in human diploid fibroblasts is accompanied by intensive enhancer-promoter rewiring, which is carefully related with dynamic cohesin binding to the genome.
We discover de novo cohesin peaks usually on the 3′ finish of a subset of lively genes. RAS-induced de novo cohesin peaks are transcription-dependent and enriched for senescence-associated genes, exemplified by IL1B, the place de novo cohesin binding is concerned in new loop formation. Related IL1B induction with de novo cohesin look and new loop formation are noticed in terminally differentiated macrophages, however not TNFα-treated cells. These outcomes counsel that RAS-induced senescence represents a cell destiny determination-like course of characterised by a singular gene expression profile and 3D genome folding signature, mediated partially by way of cohesin redistribution on chromatin.
The massive quantity of information acquired by high-throughput sequencing requires information discount for efficient evaluation. Right here we give a clustering algorithm for genome-wide open chromatin information utilizing a brand new information discount technique. This technique regards the genome as a string of 1s and 0s primarily based on a set of peaks and calculates the Hamming distances between the strings. This algorithm with the systematically optimized set of peaks permits us to quantitatively consider variations between samples of hematopoietic cells and classify cell varieties, doubtlessly resulting in a greater understanding of leukemia pathogenesis.
Three-dimensional chromatin organization in cardiac development and disease
Latest technological developments within the discipline of chromatin biology have rewritten the textbook on nuclear group. We now respect that the folding of chromatin within the three-dimensional area (i.e. its 3D “structure”) is non-random, hierarchical, and extremely advanced. Whereas 3D chromatin construction is partially encoded within the main sequence and thereby broadly conserved throughout cell varieties and states, a considerable portion of the genome appears to be dynamic throughout improvement or in illness. Furthermore, there’s rising proof that at the very least a few of the 3D construction of chromatin is functionally linked to gene regulation, each being modulated by and impacting on a number of nuclear processes (together with DNA replication, transcription, and RNA splicing).
In recent times, these new ideas have nourished a number of investigations concerning the purposeful function of 3D chromatin topology dynamics within the coronary heart throughout improvement and illness. This assessment goals to supply a complete overview of our present understanding on this discipline, and to debate how this information can inform additional analysis in addition to scientific apply. Past being the product of gene expression, RNA may affect the regulation of chromatin. Nearly all of the human genome has the capability to be transcribed and nearly all of the non-protein-coding transcripts made by RNA Polymerase II are enriched within the nucleus.
DiscoveryProbe? Bioactive Compound Library |
L1022-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 50450.4 |
DiscoveryProbe? Bioactive Compound Library |
L1022-5 |
ApexBio |
5 mg/well |
EUR 65623.2 |
DiscoveryProbe? Kinase Inhibitor Library |
L1024-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 7520.4 |
DiscoveryProbe? Kinase Inhibitor Library |
L1024-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 13394.4 |
DiscoveryProbe? Kinase Inhibitor Library |
L1024-5 |
ApexBio |
5 mg/well |
EUR 17473.2 |
DiscoveryProbe? GPCR Compound Library |
L1025-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 5683.2 |
DiscoveryProbe? GPCR Compound Library |
L1025-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 10221.6 |
DiscoveryProbe? GPCR Compound Library |
L1025-5 |
ApexBio |
5 mg/well |
EUR 13284 |
DiscoveryProbe? Neuronal Signaling Library |
L1026-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 5961.6 |
DiscoveryProbe? Neuronal Signaling Library |
L1026-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 10639.2 |
DiscoveryProbe? Neuronal Signaling Library |
L1026-5 |
ApexBio |
5 mg/well |
EUR 13840.8 |
DiscoveryProbe? Epigenetics Compound Library |
L1029-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 7144.8 |
DiscoveryProbe? Epigenetics Compound Library |
L1029-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 12866.4 |
DiscoveryProbe? Epigenetics Compound Library |
L1029-5 |
ApexBio |
5 mg/well |
EUR 16764 |
DiscoveryProbe? Autophagy Compound Library |
L1031-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 13408.8 |
DiscoveryProbe? Autophagy Compound Library |
L1031-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 24141.6 |
DiscoveryProbe? Autophagy Compound Library |
L1031-5 |
ApexBio |
5 mg/well |
EUR 31380 |
DiscoveryProbe? Protease Inhibitor Library |
L1035-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4068 |
DiscoveryProbe? Protease Inhibitor Library |
L1035-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 7214.4 |
DiscoveryProbe? Protease Inhibitor Library |
L1035-5 |
ApexBio |
5 mg/well |
EUR 9414 |
DiscoveryProbe? Apoptosis Compound Library |
L1036-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4166.4 |
DiscoveryProbe? Apoptosis Compound Library |
L1036-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 7437.6 |
DiscoveryProbe? Apoptosis Compound Library |
L1036-5 |
ApexBio |
5 mg/well |
EUR 9664.8 |
DiscoveryProbe? Cell Cycle Library |
L1037-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 2078.4 |
DiscoveryProbe? Cell Cycle Library |
L1037-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 3664.8 |
DiscoveryProbe? Cell Cycle Library |
L1037-5 |
ApexBio |
5 mg/well |
EUR 4778.4 |
DiscoveryProbe? Histone Modification Library |
L1038-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 2230.8 |
DiscoveryProbe? Histone Modification Library |
L1038-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 3970.8 |
DiscoveryProbe? Histone Modification Library |
L1038-5 |
ApexBio |
5 mg/well |
EUR 5210.4 |
DiscoveryProbe? Natural Product Library |
L1039-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 5529.6 |
DiscoveryProbe? Natural Product Library |
L1039-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 9943.2 |
DiscoveryProbe? Natural Product Library |
L1039-5 |
ApexBio |
5 mg/well |
EUR 12866.4 |
DiscoveryProbe? MAPK Inhibitor Library |
L1043-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 2384.4 |
DiscoveryProbe? MAPK Inhibitor Library |
L1043-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 4249.2 |
DiscoveryProbe? MAPK Inhibitor Library |
L1043-5 |
ApexBio |
5 mg/well |
EUR 5488.8 |
DiscoveryProbe? Angiogenesis-related Compounds Panel |
L1001-5 |
ApexBio |
5 mg/well |
EUR 1278 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to angiogenesis, including Btk, integrin and HIF-1 etc. Facilitate your research towards the insights of tumorigenesis, cardiovascular disease and wound repair etc. |
DiscoveryProbe? Apoptosis-related Compounds Panel |
L1002-5 |
ApexBio |
5 mg/well |
EUR 3120 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to apoptosis, including caspase, MDM2 and Bcl-2 etc. Facilitate your research towards the insights of cancer, degenerative diseases and autoimmunity etc. |
DiscoveryProbe? Cardiovascular-related Compounds Panel |
L1004-5 |
ApexBio |
5 mg/well |
EUR 3928.8 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to cardiovascular system, including angiotensin and thrombin etc. Facilitate your research towards the insights of vascular disease, stroke, wound repair and cancer etc. |
DiscoveryProbe? Metabolism-related Compounds Panel |
L1013-5 |
ApexBio |
5 mg/well |
EUR 7617.6 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to metabolism, including PPAR, HMG-CoA reductase, HSP, PDE and DHFR etc. Facilitate your research towards the insights of diabetes, hypertension ad hormone regulation etc. |
DiscoveryProbe? Neuroscience-related Compounds Panel |
L1015-5 |
ApexBio |
5 mg/well |
EUR 10249.2 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to neuroscience, including 5-HT Receptor, Amyloid ?, GABA and COX etc. Facilitate your research towards the insights of Alzheimer disease, Parkinson's disease and epilepsy etc. |
DiscoveryProbe? Ubiquitination-related Compounds Panel |
L1019-5 |
ApexBio |
5 mg/well |
EUR 3400.8 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to ubiquitination, including autophagy, proteasome and p97 etc. Facilitate your research towards the insights of cancer, diabetes, neurodegenerative and cardiovascular diseases etc. |
DiscoveryProbe? FDA-approved Drug Library |
L1021-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 6811.2 |
Description: DiscoveryProbe? FDA-approved drug library includes 1496 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS). It can be used to find new targets for old drugs. The bioactivity and safety of these drugs were confirmed by clinical trials. |
DiscoveryProbe? FDA-approved Drug Library |
L1021-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 12170.4 |
Description: DiscoveryProbe? FDA-approved drug library includes 1496 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS). It can be used to find new targets for old drugs. The bioactivity and safety of these drugs were confirmed by clinical trials. |
DiscoveryProbe? FDA-approved Drug Library |
L1021-0.05 |
ApexBio |
50 uL/well(10 mM solution) |
EUR 4514.4 |
Description: DiscoveryProbe? FDA-approved drug library includes 1496 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS). It can be used to find new targets for old drugs. The bioactivity and safety of these drugs were confirmed by clinical trials. |
DiscoveryProbe? FDA-approved Drug Library |
L1021-5 |
ApexBio |
5 mg/well |
EUR 15789.6 |
Description: DiscoveryProbe? FDA-approved drug library includes 1496 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS). It can be used to find new targets for old drugs. The bioactivity and safety of these drugs were confirmed by clinical trials. |
DiscoveryProbe? Anti-cancer Compound Library |
L1023-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 24363.6 |
DiscoveryProbe? Anti-cancer Compound Library |
L1023-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 43768.8 |
DiscoveryProbe? Anti-cancer Compound Library |
L1023-5 |
ApexBio |
5 mg/well |
EUR 56853.6 |
DiscoveryProbe? Anti-infection Compound Library |
L1027-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 8439.6 |
DiscoveryProbe? Anti-infection Compound Library |
L1027-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 15093.6 |
DiscoveryProbe? Anti-infection Compound Library |
L1027-5 |
ApexBio |
5 mg/well |
EUR 19548 |
DiscoveryProbe? Tyrosine Kinase Inhibitor Library |
L1028-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 6476.4 |
DiscoveryProbe? Tyrosine Kinase Inhibitor Library |
L1028-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 11613.6 |
DiscoveryProbe? Tyrosine Kinase Inhibitor Library |
L1028-5 |
ApexBio |
5 mg/well |
EUR 15093.6 |
DiscoveryProbe? Ion Channel Compound Library |
L1030-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 6672 |
DiscoveryProbe? Ion Channel Compound Library |
L1030-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 11863.2 |
DiscoveryProbe? Ion Channel Compound Library |
L1030-5 |
ApexBio |
5 mg/well |
EUR 15482.4 |
DiscoveryProbe? Metabolism-related Compound Library |
L1032-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 10291.2 |
DiscoveryProbe? Metabolism-related Compound Library |
L1032-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 18434.4 |
DiscoveryProbe? Metabolism-related Compound Library |
L1032-5 |
ApexBio |
5 mg/well |
EUR 24002.4 |
DiscoveryProbe? Stem Cell Compound Library |
L1040-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 5223.6 |
DiscoveryProbe? Stem Cell Compound Library |
L1040-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 9386.4 |
DiscoveryProbe? Stem Cell Compound Library |
L1040-5 |
ApexBio |
5 mg/well |
EUR 12170.4 |
DiscoveryProbe? JAK/STAT Compound Library |
L1041-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 2704.8 |
DiscoveryProbe? JAK/STAT Compound Library |
L1041-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 4792.8 |
DiscoveryProbe? JAK/STAT Compound Library |
L1041-5 |
ApexBio |
5 mg/well |
EUR 6184.8 |
DiscoveryProbe? Immunology/Inflammation Compound Library |
L1042-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4068 |
DiscoveryProbe? Immunology/Inflammation Compound Library |
L1042-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 7298.4 |
DiscoveryProbe? Immunology/Inflammation Compound Library |
L1042-5 |
ApexBio |
5 mg/well |
EUR 9525.6 |
DiscoveryProbe? NF-?B Signaling Library |
L1044-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 1730.4 |
DiscoveryProbe? NF-?B Signaling Library |
L1044-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 3052.8 |
DiscoveryProbe? NF-?B Signaling Library |
L1044-5 |
ApexBio |
5 mg/well |
EUR 3970.8 |
DiscoveryProbe? Anti-diabetic Compound Library |
L1046-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 866.4 |
DiscoveryProbe? Anti-diabetic Compound Library |
L1046-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 1507.2 |
DiscoveryProbe? Anti-diabetic Compound Library |
L1046-5 |
ApexBio |
5 mg/well |
EUR 1939.2 |
DiscoveryProbe? Natural Product Library Plus |
L1049-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4232.4 |
DiscoveryProbe? Natural Product Library Plus |
L1049-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 7503.6 |
DiscoveryProbe? Natural Product Library Plus |
L1049-5 |
ApexBio |
5 mg/well |
EUR 9786 |
DiscoveryProbe? Cancer Biology-related Compounds Panel |
L1003-5 |
ApexBio |
5 mg/well |
EUR 4736.4 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to cancer biology, including p53, EGFR and PKC etc. Facilitate your research towards the insights of gene regulation, tumorgenesis and immunotherapy etc. |
DiscoveryProbe? Immunology/Inflammation-related Compounds Panel |
L1010-5 |
ApexBio |
5 mg/well |
EUR 3219.6 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to immunology/inflammation, including TLR, PLA2 and NF-?B etc. Facilitate your research towards the insights of cancer, inflammatory and autoimmune diseases etc. |
DiscoveryProbe? Microbiology & Virology-related Compounds Panel |
L1014-5 |
ApexBio |
5 mg/well |
EUR 6267.6 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to microbiology & virology, including CCR5, HSV and CMV etc. Facilitate your research towards the insights of infection, immune diseases and cancer etc. |
DiscoveryProbe? Proteases/Proteasome-related Compounds Panel |
L1016-5 |
ApexBio |
5 mg/well |
EUR 10262.4 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to proteases/proteasome, including cathepsin, DUB and gamma secretaseand HCV protease etc. |
DiscoveryProbe? Stem Cell-related Compounds Panel |
L1017-5 |
ApexBio |
5 mg/well |
EUR 6824.4 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to stem cell, including hedgehog, smoothened and Wnt/?-catenin etc. Facilitate your research towards the insights of cell proliferation, growth and differentiation etc. |
DiscoveryProbe? MAPK Signaling Pathway Compounds Panel |
L1020-5 |
ApexBio |
5 mg/well |
EUR 5320.8 |
Description: A wide range of well-characterized bioactive molecules that covers various targets on the MAPK signaling pathway, including MEK1/2, p38 and Raf etc. Facilitate your research towards the insights of cell proliferation, differentiation, apoptosis and motility etc. |
DiscoveryProbe? DNA Damage/DNA Repair Library |
L1033-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4666.8 |
DiscoveryProbe? DNA Damage/DNA Repair Library |
L1033-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 8286 |
DiscoveryProbe? DNA Damage/DNA Repair Library |
L1033-5 |
ApexBio |
5 mg/well |
EUR 10806 |
DiscoveryProbe? PI3K/Akt/mTOR Compound Library |
L1034-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 4500 |
DiscoveryProbe? PI3K/Akt/mTOR Compound Library |
L1034-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 7994.4 |
DiscoveryProbe? PI3K/Akt/mTOR Compound Library |
L1034-5 |
ApexBio |
5 mg/well |
EUR 10360.8 |
DiscoveryProbe? TGF-beta/Smad Compound Library |
L1045-.1 |
ApexBio |
100 uL/well(10 mM solution) |
EUR 1966.8 |
DiscoveryProbe? TGF-beta/Smad Compound Library |
L1045-.25 |
ApexBio |
250 uL/well(10 mM solution) |
EUR 3456 |
DiscoveryProbe? TGF-beta/Smad Compound Library |
L1045-5 |
ApexBio |
5 mg/well |
EUR 4500 |
ChromaFlash Chromatin Extraction Kit |
P-2001-100 |
EpiGentek |
100 Extractions |
EUR 182.6 |
ChromaFlash Chromatin Extraction Kit |
P-2001 |
EpiGentek |
|
- 100 Extractions
- 100 Extractions
|
Holder for Plasmid Midi, Maxi and Maxi plus, Ion Exchange column |
FAPDE-holder-for-ion-exchange |
Favorgen |
1 prep |
EUR 189.6 |
DiscoveryProbe? Cell Cycle/Checkpoint-related Compounds Panel |
L1005-5 |
ApexBio |
5 mg/well |
EUR 7548 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to cell cycle/checkpoint, including Chk, CDK and Plk etc. Facilitate your research towards the insights of DNA replication, tumorgenesis and aging etc. |
DiscoveryProbe? Endocrinology and Hormones-related Compounds Panel |
L1008-5 |
ApexBio |
5 mg/well |
EUR 2829.6 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to endocrinology and hormones, including androgen receptor, estrogen/progestogen receptor and RAAS etc. Facilitate your research towards the insights of diabetes, thyroid disorders and cancer etc. |
DiscoveryProbe? GPCR/G protein-related Compounds Panel |
L1009-5 |
ApexBio |
5 mg/well |
EUR 7242 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to GPCR, including adenosine receptor, adrenergic receptor and CXCR etc. Facilitate your research towards the insights of cancer, neurological disorders and heart diseases etc. |
DiscoveryProbe? JAK/STAT Signaling Pathway Compounds Panel |
L1011-5 |
ApexBio |
5 mg/well |
EUR 3247.2 |
Description: A wide range of well-characterized bioactive molecules that covers various targets on the JAK/STAT signaling pathway, including EGFR, JAK and STAT etc. Facilitate your research towards the insights of differentiations, apoptosis, immunity and tumorigenesis etc. |
DiscoveryProbe? Tyrosine Kinase/Adaptors-related Compounds Panel |
L1018-5 |
ApexBio |
5 mg/well |
EUR 11668.8 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to tyrosine kinase/adaptors, including ALK, c-MET, VEGFR and Src etc. Facilitate your research towards the insights of cancer, immune response, growth and differentiation etc. |
Chromatin protein Cren7 Antibody (HRP) |
20-abx109204 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Chromatin Protein Cren7 (creN7) Antibody |
20-abx109437 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Chromatin protein Cren7 Antibody (Biotin) |
20-abx106375 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Chromatin protein Cren7 Antibody (FITC) |
20-abx107787 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
Chromatin Modifying Protein 4A Protein |
20-abx263203 |
Abbexa |
-
EUR 276.00
-
EUR 1779.60
-
EUR 393.60
|
|
|
Chromatin Modifying Protein 1A Protein |
20-abx263326 |
Abbexa |
-
EUR 1930.80
-
EUR 393.60
-
EUR 276.00
|
|
|
ATRX, Chromatin Remodeler (ATRX) Antibody |
abx331300-100ul |
Abbexa |
100 ul |
EUR 510 |
|
Chromatin Accessibility Complex 1 Protein |
20-abx261034 |
Abbexa |
-
EUR 4101.60
-
EUR 393.60
-
EUR 276.00
|
|
|
Chromatin Modifying Protein 2A Protein |
20-abx261989 |
Abbexa |
-
EUR 5388.00
-
EUR 393.60
-
EUR 276.00
|
|
|
Chromatin Modifying Protein 2B Protein |
20-abx262025 |
Abbexa |
-
EUR 5388.00
-
EUR 393.60
-
EUR 276.00
|
|
|
ATRX, Chromatin Remodeler (ATRX) Antibody |
20-abx325123 |
Abbexa |
|
|
|
EpiQuik Chromatin Accessibility Assay Kit |
P-1047-48 |
EpiGentek |
48 Reactions |
EUR 611.6 |
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit |
P-2002-1 |
EpiGentek |
24 Reactions |
EUR 312.4 |
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit |
P-2002-2 |
EpiGentek |
48 Reactions |
EUR 500.5 |
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit |
P-2002-3 |
EpiGentek |
96 Reactions |
EUR 738.1 |
ChromaFlash Plant Chromatin Extraction Kit |
P-2022-050 |
EpiGentek |
50 Extractions |
EUR 193.6 |
ChromaFlash Chromatin Isolation & Shearing Kit |
P-2023-100 |
EpiGentek |
100 Preparations |
EUR 189.2 |
EpiQuik Chromatin Accessibility Assay Kit |
P-1047 |
EpiGentek |
|
|
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit |
P-2002 |
EpiGentek |
-
EUR 1084.86
-
EUR 312.40
-
EUR 500.50
-
EUR 738.10
|
- 96 Reactions
- 24 Reactions
- 48 Reactions
- 96 Reactions
|
ChromaFlash Plant Chromatin Extraction Kit |
P-2022 |
EpiGentek |
|
- 50 Extractions
- 50 Extractions
|
ChromaFlash Chromatin Isolation & Shearing Kit |
P-2023 |
EpiGentek |
|
- 100 Preperations
- 100 Preparations
|
ELISA kit for Mouse CHAF1B (Chromatin Assembly Factor 1, Subunit B) |
ELK6320 |
ELK Biotech |
1 plate of 96 wells |
EUR 518.4 |
|
Description: A sandwich ELISA kit for detection of Chromatin Assembly Factor 1, Subunit B from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
DiscoveryProbe? DNA Damage/DNA Repair-related Compounds Panel |
L1007-5 |
ApexBio |
5 mg/well |
EUR 7172.4 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to DNA damage/DNA repair, including ATM/ATR, HDAC, and topoisomerase etc. Facilitate your research towards the insights of cancer, genome instability and immune diseases etc. |
DiscoveryProbe? Membrane Transporter/Ion Channel-related Compounds Panel |
L1012-5 |
ApexBio |
5 mg/well |
EUR 3776.4 |
Description: A wide range of well-characterized bioactive molecules that covers various targets related to membrane transporter/ion channel, including ATPase, calcium channel and CFTR etc. Facilitate your research towards the insights of heart diseases, cystic fibrosis and immune disorders etc. |
Recombinant Human Chromatin Modifying Protein 2A |
7-04807 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Chromatin Modifying Protein 2A |
7-04808 |
CHI Scientific |
20µg |
Ask for price |
Recombinant Human Chromatin Modifying Protein 2A |
7-04809 |
CHI Scientific |
1mg |
Ask for price |
Recombinant Human Chromatin Modifying Protein 2B |
7-04810 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Chromatin Modifying Protein 2B |
7-04811 |
CHI Scientific |
20µg |
Ask for price |
Recombinant Human Chromatin Modifying Protein 2B |
7-04812 |
CHI Scientific |
1mg |
Ask for price |
Many chromatin regulators can bind to those ncRNAs within the nucleus; in some circumstances, there are clear examples of direct RNA-mediated chromatin regulation mechanisms stemming from these interactions, whereas others have but to be decided. Latest research have highlighted examples of chromatin regulation through RNA matchmaking, a time period we use broadly right here to explain intermolecular base-pairing interactions between one RNA molecule and an RNA or DNA match.